Genetic Test for Progression of Adolescent Idiopathic Scoliosis

Full Title of Study

Genetic Research to Develop a Diagnostic Tool for the Progression of Adolescent Idiopathic Scoliosis (AIS)

Purpose of Study

There is currently a genetic test that may help determine whether the spinal curve in patients with adolescent idiopathic scoliosis (AIS) is more or less likely to progress to a stage that requires surgical intervention. The test is currently is available only to a small group of patients—specifically, Caucasian females between the ages of 9 and 13 years with minor curves between 10 and 25 degrees. The purpose of this study is to collect many samples from diverse groups of patients in order to make this test applicable to all ethnicities and both genders.

Basic Inclusion Criteria (requirements for being included in study)

Diagnosis of adolescent idiopathic scoliosis
Documentation of three visits with the study’s principal investigator (Dr. Lonner) or another physician
Has either reached skeletal maturity or has completed surgical treatment

Basic Exclusion Criteria (reasons for being excluded from study)

Patients with adult-onset, congenital, infantile, degenerative, neuromuscular, trauma-related, or syndromic scoliosis
Skeletally immature nonsurgical patients
No initial or final cobb angle
Incomplete or unavailable clinical notes

Study Visit Requirements

None

Principal Investigator

Baron Lonner, MD